Cholesterol Side-Chain Cleavage Enzyme

A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.

Also Known As:

CYP11A1; Cholesterol Monooxygenase (Side-Chain-Cleaving); 20,22-Desmolase; CYP 11A1; Cytochrome P450 11A1; Cytochrome P450scc; 20,22 Desmolase; Cholesterol Side Chain Cleavage Enzyme; Cytochrome P 450 CYP11A1; Cholesterol Desmolase; Cytochrome P-450 CYP11A1; Cytochrome P-450(scc); Cholesterol,reduced- adrenal- ferredoxin:oxygen oxidoreductase (side-chain-cleaving)

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Oxygenases: 336
      - Mixed Function Oxygenases: 2207
        Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 11: 13
        Cholesterol Side-Chain Cleavage Enzyme: 212
        Steroid Hydroxylases: 11
        Cholesterol Side-Chain Cleavage Enzyme: 212
- Cytochromes: 2210
  - Cytochrome P-450 Enzyme System: 5452
    - Cytochrome P450 Family 11: 13
      - Cholesterol Side-Chain Cleavage Enzyme: 212
    - Steroid Hydroxylases: 11
      - Cholesterol Side-Chain Cleavage Enzyme: 212
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Hemeproteins: 196
    - Cytochromes: 2210
      - Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 11: 13
        Cholesterol Side-Chain Cleavage Enzyme: 212
        Steroid Hydroxylases: 11
        Cholesterol Side-Chain Cleavage Enzyme: 212

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Disease

Drug/Important Bio-Agent (IBA)